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Article

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004

Evans Matthew J, Rice Charles M, Goff Stephen P

Abstract excerpt

The study of the hepatitis C virus (HCV) has been hindered by the lack of in vitro model systems. The recent development of HCV subgenomic RNA replicons has permitted the study of viral RNA replication in cell culture; however, the requirements for efficient replication of replicons in this system are poorly understood. Many viral isolates do not function as replicons and most require conserved changes, termed...

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Identifiers

PMID: 15326295
DOI: 10.1073/pnas.0405152101
PMCID: PMC516513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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