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Propagation of Benchmarking Uncertainty Through Downstream Analysis: From Network Inference Ranking to Biological Discovery

2026-04-17

Abstract excerpt

Rank-based benchmarking is the standard approach for evaluating Gene Regulatory Network (GRN) inference methods. However, recent work has revealed substantial ranking instability across common evaluation protocol axes, such as choice of gold standard reference, similarity metric, or thresholding strategy. While this instability calls method rankings into question, its downstream biological consequences remain larg...

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Literature Corpus work: 087af37a-ca1b-57a9-a19a-5dd1cdd0ad0f
DOI: 10.14293/pr2199.003412.v1

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