Article

Signature Recontextualization: Mapping perturbational signatures across biological contexts

2026-08-19

Abstract excerpt

Perturbational transcriptomics is a powerful tool for understanding gene function and drug effects, yet predicting how perturbations manifest across different biological contexts remains a central challenge, limiting translation from model systems to clinically relevant tissues. Despite growing interest in this problem, benchmarking efforts have been hindered by inconsistent evaluation tasks, heterogeneous metrics...

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Literature Corpus work: 694b9863-81f3-5d03-89a0-28ffaaf70ee5
DOI: 10.64898/2026.08.14.744937

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