Article

Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer

2021-11-13

Abstract excerpt

Therapy resistance in cancer is often driven by a subpopulation of cells that are temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose mutational drivers remain largely unknown. We developed methodology to robustly identify this state from transcriptomic signals and characterised its prevalence and genomic constraints in solid primary tumours. We show that G0 arrest prefere...

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Literature Corpus work: 0874484c-549a-5486-8b97-3c4c43325f3b
DOI: 10.1101/2021.11.12.468410

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