Article
Genomic hallmarks of cellular dormancy in cancer and therapeutic implications
2021-11-24
Abstract excerpt
<title>Abstract</title> <p>Therapy resistance in cancer is often driven by a subpopulation of cells that are temporarily arrested in a non-proliferative, quiescent or ‘dormant’ state, which is difficult to capture and whose mutational drivers remain largely unknown. We developed methodology to uniquely identify this state from transcriptomic signals and characterised its prevalence and genomic constraints in soli...
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Identifiers and source
- Literature Corpus work
- 8f33c961-6022-57f2-91c9-ff441cdddd75
- DOI
- 10.21203/rs.3.rs-1104031/v1