Common phenotypic dynamics of tumor-infiltrating lymphocytes across different histologies upon checkpoint inhibition: impact on clinical outcome.

doi:10.1016/j.jcyt.2020.01.010

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Article

Common phenotypic dynamics of tumor-infiltrating lymphocytes across different histologies upon checkpoint inhibition: impact on clinical outcome.

Cytotherapy - 1 Apr 2020

Araujo B de Lima Vinicius, Borch Annie, Hansen Morten, Draghi Arianna, Spanggaard Iben, Rohrberg Kristoffer, Reker Hadrup Sine, Lassen Ulrik, Svane Inge Marie

Abstract excerpt

BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized the cancer therapeutic landscape and our perception of interactions between the immune system and tumor cells. Despite remarkable progress, disease relapse and primary resistance are not uncommon. Understanding the biological processes that tumor-infiltrating lymphocytes (TILs) undergo during ICI, how this affects the tumor microenvironment (TME)...

Topics

Adult
Aged
B7-H1 Antigen
Biopsy
CD8-Positive T-Lymphocytes
Female
Follow-Up Studies
Humans
Immunologic Factors
Immunotherapy
Lymphocytes, Tumor-Infiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Targeted Therapy

Neoplasms

Phenotype

Programmed Cell Death 1 Receptor

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 32201034
DOI: 10.1016/j.jcyt.2020.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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