Article

Structural basis of stereochemical promiscuity by an umami taste receptor ortholog, Tas1r1/Tas1r3 from pufferfish

2025-11-25

Abstract excerpt

Taste receptor type 1 (TAS1R), which consists of sweet and umami receptors in humans, senses nutrients (such as sugars and amino acids) with substrate specificity that is often broad and varies among animals and subtypes. However, the structural basis for achieving diverse specificities remains largely elusive. Here, we present the crystal structure of the ligand-binding domain (LBD) of Tas1r1/Tas1r3 heterodimer f...

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Literature Corpus work: 0865b8a4-44b0-52ee-9b42-6c4db51b7fc1
DOI: 10.1101/2025.11.24.689453

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Structural basis of stereochemical promiscuity by an umami taste receptor ortholog, Tas1r1/Tas1r3 from pufferfishDOI 10.1101/2025.11.24.689453Read

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