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<i>O</i> <sup>6</sup> -Alkylguanine-DNA Alkyltransferase Maintains Genomic Integrity During Peroxynitrite-Mediated DNA Damage by Forming DNA-Protein Crosslinks

2024-02-24

Abstract excerpt

Inflammation is an early immune response against invading pathogens and damaged tissue. Although beneficial, uncontrolled inflammation leads to various diseases and may be fatal. Peroxynitrite (PN) is a major reactive nitrogen species (RNS) generated during inflammation. It produces various DNA lesions including labile 8-nitroguanine which spontaneously converts into abasic sites resulting in DNA strand breakage....

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Literature Corpus work
085d70b8-4b63-507f-a3c1-2294f6b4dec1
DOI
10.1101/2024.02.22.581550
Open publication

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