Cancer Development and Progression Through a Vicious Cycle of DNA Damage and Inflammation

doi:10.3390/ijms26073352

Article

Cancer Development and Progression Through a Vicious Cycle of DNA Damage and Inflammation

3 Apr 2025

Abstract excerpt

Infections and chronic inflammation play a crucial role in the development of cancer. During inflammatory processes, reactive oxygen and nitrogen species are generated by both inflammatory and epithelial cells, leading to the induction of oxidative and nitrative DNA damage, such as the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine (8-nitroG). These DNA alterations can trigger...

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