Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained.

Abstract excerpt

Mice susceptible to plasma cell tumors provide a useful model for human multiple myeloma. We previously showed that mice expressing an Eµ-v-abl oncogene solely develop plasmacytomas. Here we show that loss of the proapoptotic BH3-only protein Bim or, to a lesser extent, overexpression of antiapoptotic Bcl-2 or Mcl-1, significantly accelerated the development of plasmacytomas and increased their incidence. Disease...

Topics

• Animals
• Apoptosis
• Apoptosis Regulatory Proteins
• Bcl-2-Like Protein 11
• Blotting, Western
• Cells, Cultured
• Cyclin D1
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Kaplan-Meier Estimate
• Membrane Proteins
• Mice, Inbred C57BL
• Mice, Knockout