Article

A mutation in vesicular acetylcholine transporter increases tubulin acetylation compromising synaptic vesicle transport

2024-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Kinesin-3 UNC-104(KIF1A) is the major anterograde axonal transporter of synaptic vesicles and is expressed pan-neuronally. Genetic defects in this molecular motor are linked to KIF1A-associated neurological disorders (KAND) encompassing Charcot-Marie-Tooth (CMT) disease and hereditary spastic paraplegia (HSP). From a candidate screen for genes causing neurotransmission defects in C. elegans and...

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Literature Corpus work: 082c2d58-b036-5844-bb81-13834b86ea26
DOI: 10.1101/2024.06.06.597842

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