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Article

A Mutation in Vesicular Acetylcholine Transporter Increases Tubulin Acetylation Compromising Synaptic Vesicle Transport.

Journal of neurochemistry - 1 Dec 2025

Kuo Cheng-Shan, Ruckmani Vignesh Mahendran, Wang Meng-Chieh, Khawaja Muhammad Safwan, Bayansan Odvogmed, Barmaver Syed Nooruzuha, Bhan Prerana, Wagner Oliver Ingvar

Abstract excerpt

Kinesin-3 UNC-104(KIF1A) is the major anterograde axonal transporter of synaptic vesicles and is expressed pan-neuronally. Genetic defects in this molecular motor are linked to KIF1A-associated neurological disorders (KAND), a spectrum of severe neurological conditions encompassing Charcot-Marie-Tooth (CMT) disease and hereditary spastic paraplegia (HSP). From a candidate screen for genes causing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41452330
DOI: 10.1111/jnc.70322

Genes

KIF1A
ATAT1
SLC18A3

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A Mutation in Vesicular Acetylcholine Transporter Increases Tubulin Acetylation Compromising Synaptic Vesicle Transport.PMID 41452330Read ↗

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