Article

Genetic association analyses highlight IL6 , ALPL , and NAV1 as three new susceptibility genes underlying calcific aortic valve stenosis

2019-01-11

Abstract excerpt

To date, only two replicated loci, LPA and PALMD , have been identified as causal genes for calcific aortic valve stenosis (CAVS) using genome-wide and transcriptome-wide association study (TWAS). To identify additional susceptibility genes for CAVS, we performed a GWAS meta-analysis totaling 5,115 cases and 354,072 controls of European descent. Four loci achieved genome-wide significance, including two new loci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 081e191b-2ba1-54cc-8886-d850cb934103
DOI: 10.1101/515494

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic association analyses highlight IL6 , ALPL , and NAV1 as three new susceptibility genes underlying calcific aortic valve stenosisDOI 10.1101/515494Read

Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.Semantic proximity Read

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Semantic proximity Read

Genetic and Epigenetic Regulation of Inflammatory Genes Drives Calcific Aortic Valve Disease (CAVD)Semantic proximity Read

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosisSemantic proximity Read

Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.Semantic proximity Read

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.Semantic proximity Read

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulationSemantic proximity Read

Genome-wide analysis yields new loci associating with aortic valve stenosisSemantic proximity Read

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.Semantic proximity Read

Genetics of Calcific Aortic Stenosis: A Systematic Review.Semantic proximity Read

Genome-wide analysis yields new loci associating with aortic valve stenosis.Semantic proximity Read

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesisSemantic proximity Read

Genetic association analyses highlight <i>IL6</i> , <i>ALPL</i> , and <i>NAV1</i> as three new susceptibility genes underlying calcific aortic valve stenosis

Abstract excerpt

Topics

Identifiers and source

Related research