Article
Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.
European heart journal - 1 Jun 2023
Yu Chen Hao, Dina Christian, Small Aeron M, Shaffer Christian M, Levinson Rebecca T, Helgadóttir Anna, Capoulade Romain, Munter Hans Markus, Martinsson Andreas, Cairns Benjamin J, Trudsø Linea C, Hoekstra Mary, Burr Hannah A, Marsh Thomas W, Damrauer Scott M, Dufresne Line, Le Scouarnec Solena, Messika-Zeitoun David, Ranatunga Dilrini K, Whitmer Rachel A, Bonnefond Amélie, Sveinbjornsson Garðar, Daníelsen Ragnar, Arnar David O, Thorgeirsson Gudmundur, Thorsteinsdottir Unnur, Gudbjartsson Daníel F, Hólm Hilma, Ghouse Jonas, Olesen Morten Salling, Christensen Alex H, Mikkelsen Susan, Jacobsen Rikke Louise, Dowsett Joseph, Pedersen Ole Birger Vesterager, Erikstrup Christian, Ostrowski Sisse R, O'Donnell Christopher J, Budoff Matthew J, Gudnason Vilmundur, Post Wendy S, Rotter Jerome I, Lathrop Mark, Bundgaard Henning, Johansson Bengt, Ljungberg Johan, Näslund Ulf, Le Tourneau Thierry, Smith J Gustav, Wells Quinn S, Söderberg Stefan, Stefánsson Kári, Schott Jean-Jacques, Rader Daniel J, Clarke Robert, Engert James C, Thanassoulis George
Abstract excerpt
AIMS: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. METHODS AND RESULTS: A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry...
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