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Article

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.

Nature communications - 7 Mar 2018

Thériault Sébastien, Gaudreault Nathalie, Lamontagne Maxime, Rosa Mickael, Boulanger Marie-Chloé, Messika-Zeitoun David, Clavel Marie-Annick, Capoulade Romain, Dagenais François, Pibarot Philippe, Mathieu Patrick, Bossé Yohan

Abstract excerpt

Calcific aortic valve stenosis (CAVS) is a common and life-threatening heart disease and the current treatment options cannot stop or delay its progression. A GWAS on 1009 cases and 1017 ethnically matched controls was combined with a large-scale eQTL mapping study of human aortic valve tissues (n = 233) to identify susceptibility genes for CAVS. Replication was performed in the UK Biobank, including 1391 cases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29511167
DOI: 10.1038/s41467-018-03260-6
PMCID: PMC5840407

Genes

PALMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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