Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.

doi:10.1161/CIRCGEN.119.002617

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Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.

Circulation. Genomic and precision medicine - 1 Oct 2019

Thériault Sébastien, Dina Christian, Messika-Zeitoun David, Le Scouarnec Solena, Capoulade Romain, Gaudreault Nathalie, Rigade Sidwell, Li Zhonglin, Simonet Floriane, Lamontagne Maxime, Clavel Marie-Annick, Arsenault Benoit J, Boureau Anne-Sophie, Lecointe Simon, Baron Estelle, Bonnaud Stéphanie, Karakachoff Matilde, Charpentier Eric, Fellah Imen, Roussel Jean-Christian, Philippe Verhoye Jean, Baufreton Christophe, Probst Vincent, Roussel Ronan, Redon Richard, Dagenais François, Pibarot Philippe, Mathieu Patrick, Le Tourneau Thierry, Bossé Yohan, Schott Jean-Jacques

Abstract excerpt

BACKGROUND: Calcific aortic valve stenosis (CAVS) is a frequent and life-threatening cardiovascular disease for which there is currently no medical treatment available. To date, only 2 genes, LPA and PALMD, have been identified as causal for CAVS. We aimed to identify additional susceptibility genes for CAVS. METHODS: A GWAS (genome-wide association study) meta-analysis of 4 cohorts, totaling 5115 cases and...

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PMID: 32141789
DOI: 10.1161/CIRCGEN.119.002617

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