Article

A transcriptome-wide association study identifies <i>PALMD</i> as a susceptibility gene for calcific aortic valve stenosis

2017-09-05

Abstract excerpt

Calcific aortic valve stenosis (CAVS) is a common and life-threatening heart disease with no drug that can stop or delay its progression. Elucidating the genetic factors underpinning CAVS is an urgent priority to find new therapeutic targets 1 . Major landmarks in genetics of CAVS include the discoveries of NOTCH1 2 and LPA 3 . However, genetic variants in these genes accounted for a small number of cases and l...

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Literature Corpus work: e565f940-c6d2-5edf-bcd0-55287950b201
DOI: 10.1101/184945

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