Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.

Circulation. Cardiovascular genetics - 1 Dec 2015

Guauque-Olarte Sandra, Messika-Zeitoun David, Droit Arnaud, Lamontagne Maxime, Tremblay-Marchand Joël, Lavoie-Charland Emilie, Gaudreault Nathalie, Arsenault Benoit J, Dubé Marie-Pierre, Tardif Jean-Claude, Body Simon C, Seidman Jonathan G, Boileau Catherine, Mathieu Patrick, Pibarot Philippe, Bossé Yohan

Abstract excerpt

BACKGROUND: Calcific aortic valve stenosis (AS) is a life-threatening disease with no medical therapy. The genetic architecture of AS remains elusive. This study combines genome-wide association studies, gene expression, and expression quantitative trait loci mapping in human valve tissues to identify susceptibility genes of AS. METHODS AND RESULTS: A meta-analysis was performed combining the results of 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Valve
Share to Aortic Valve Stenosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcinosis

Share to Calcium Channels, L-Type

Share to Calcium Signaling

Share to Core Binding Factor Alpha 1 Subunit

Share to Databases, Genetic

Share to Genome-Wide Association Study

Source

Open in PubMed Open full text

Identifiers

PMID: 26553695
DOI: 10.1161/CIRCGENETICS.115.001145
PMCID: PMC4934886

Genes

RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.PMID 26553695Read ↗

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Semantic proximity Read ↗

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulationSemantic proximity Read ↗

Genomics: the next step to elucidate the etiology of calcific aortic valve stenosis.Semantic proximity Read ↗

Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues.Semantic proximity Read ↗

Genetics of Calcific Aortic Stenosis: A Systematic Review.Semantic proximity Read ↗

Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.Semantic proximity Read ↗

Genome-wide analysis yields new loci associating with aortic valve stenosis.Semantic proximity Read ↗

Genetic and Epigenetic Regulation of Inflammatory Genes Drives Calcific Aortic Valve Disease (CAVD)Semantic proximity Read ↗

Molecular genetics of aortic valve diseaseSemantic proximity Read ↗

Genetic association analyses highlight <i>IL6</i> , <i>ALPL</i> , and <i>NAV1</i> as three new susceptibility genes underlying calcific aortic valve stenosisSemantic proximity Read ↗

Identifying miRNA-TF-mRNA Regulatory Network for Aortic Valve Calcification Diseases Through Bioinformatics AnalysisSemantic proximity Read ↗

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.