Article

Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome

2021-02-08

Abstract excerpt

Copy Number Variation (CNV) at the 1q21.1 locus is associated with a range of neurodevelopmental and psychiatric disorders in humans, including abnormalities in head size and motor deficits. Yet, the functional consequences of these CNVs (both deletion and duplication) on neuronal development remain unknown. To determine the impact of CNV at the 1q21.1 locus on neuronal development, we generated induced pluripoten...

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Literature Corpus work: 08103eaa-4b5f-50f5-b2ac-1ebdec692cf1
DOI: 10.1101/2021.02.08.430246

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