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Article

Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers.

Journal of experimental & clinical cancer research : CR - 4 Mar 2020

Federici Giulia, Soddu Silvia

Abstract excerpt

The promising expectations about personalized medicine have opened the path to routine large-scale sequencing and increased the importance of genetic counseling for hereditary cancers, among which hereditary breast and ovary cancers (HBOC) have a major impact. High-throughput sequencing, or Next-Generation Sequencing (NGS), has improved cancer patient management, ameliorating diagnosis and treatment decisions. In...

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Identifiers

PMID: 32127026
DOI: 10.1186/s13046-020-01554-6
PMCID: PMC7055088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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