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Article

Hereditary breast and ovarian cancer: new genes in confined pathways.

Nature reviews. Cancer - 1 Sept 2016

Nielsen Finn Cilius, van Overeem Hansen Thomas, Sørensen Claus Storgaard

Abstract excerpt

Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC can be ascribed to BRCA1 and BRCA2 mutations. Recently, exome sequencing has uncovered substantial locus heterogeneity among affected families without BRCA1 or BRCA2 mutations. The new pathogenic variants are rare, posing challenges to estimation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Hormone-Dependent

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Source

Identifiers

PMID: 27515922
DOI: 10.1038/nrc.2016.72

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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