Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis.

Abstract excerpt

Breast cancer is a common cancer affecting a large number of patients. Notably, 5-10% of all breast cancer patients are genetically predisposed to cancers. Although the most common breast cancer susceptibility genes are BRCA1 and BRCA2, which are also associated with the risk of developing ovarian and pancreatic cancer, advances in next-generation sequencing (NGS) analysis technology enabled the discovery of...

Topics

• BRCA1 Protein
• BRCA2 Protein
• Female
• Genetic Predisposition to Disease
• Hereditary Breast and Ovarian Cancer Syndrome
• Humans
• Mutation
• Risk Assessment