Article

An experimental target-based platform in yeast for screening <i>Plasmodium vivax</i> deoxyhypusine synthase inhibitors

2023-11-24

Abstract excerpt

<h4>ABSTRACT</h4> The enzyme deoxyhypusine synthase (DHS) catalyzes the first step in the post-translational modification of the eukaryotic translation factor 5A (eIF5A). This is the only protein known to contain the amino acid hypusine, which results from this modification. Both eIF5A and DHS are essential for cell viability in eukaryotes, and inhibiting DHS can be a promising strategy for the development of new...

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Literature Corpus work: 14248824-3fd4-5775-8113-419da428152f
DOI: 10.1101/2023.11.23.568514

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