Article

Cholecystokinin 1 Receptor (Cck1R) Normalizes mTORC1 signaling and is Protective to Purkinje cells of SCA Mice

2021-02-17

Abstract excerpt

<h4>SUMMARY</h4> Spinocerebellar Ataxias (SCAs) are a group of genetic diseases characterized by progressive ataxia and neurodegeneration, often in cerebellar Purkinje neurons. A SCA1 mouse model, Pcp2-ATXN1[30Q]D776 , has severe ataxia in absence of progressive Purkinje neuron degeneration and death. Previous RNA-seq analyses identified cerebellar up-regulation of the peptide hormone Cholecystokinin (Cck) in P...

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Literature Corpus work: 07ade81a-2d6f-5aa7-a4c2-2973489b7ebe
DOI: 10.1101/2021.02.16.431490

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