Article

Enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction

2025-03-24

Abstract excerpt

Spinocerebellar ataxias (SCAs) are autosomal dominantly inherited neurodegenerative disorders with no effective treatment. Aberrant signalling through the metabotropic glutamate receptor (mGluR1) has been implicated in several SCAs. However, whether disease is caused through decreased or increased mGluR1 signalling remains controversial. Here, we generate the first mouse model of enhanced mGluR1 function by introd...

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Literature Corpus work: 169d22e3-61a6-59a1-ac7a-f4ea772c5eeb
DOI: 10.1101/2025.03.24.644877

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