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Article

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting

1 Mar 2022

Abstract excerpt

Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related viruses with pandemic potential. Here we leverage rational immunogen design to focus humoral responses on conserved epitopes. Using glycan engineering and epitope scaffolding in...

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PMID: 35303475
DOI: 10.1016/j.celrep.2022.110561

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