Article

Expansion of OSMR expression and signaling in the human dorsal root ganglion links OSM to neuropathic pain

2025-04-01

Abstract excerpt

<h4>ABSTRACT</h4> RNA sequencing studies on human dorsal root ganglion (hDRG) from patients suffering from neuropathic pain show upregulation of OSM, linking this IL-6 family cytokine to pain disorders. In mice, however, OSM signaling causes itch behaviors through a direct effect on its cognate receptor expressed uniquely by pruriceptive sensory neurons. We hypothesized that an expansion in function of OSM-OSM re...

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Literature Corpus work: 076f32ef-570a-5ba1-b06a-1caec7994589
DOI: 10.1101/2025.03.26.645611

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