Article

Single-Soma Deep RNA Sequencing of Human Dorsal Root Ganglion Neurons Reveals Novel Molecular and Cellular Mechanisms Underlying Somatosensation

2023-03-18

Abstract excerpt

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes of individual human DRG (hDRG) neurons – critical information to decipher their functions – are lacking due to technical difficulties. Here, we developed a novel approach to isolate individual hDRG neuron somas for deep RNA sequencing (RNA-seq). On average, >9,000 unique genes per neuron we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0422cc1-904b-5e6c-8b3f-9c63ccb3d352
DOI: 10.1101/2023.03.17.533207

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Soma Deep RNA Sequencing of Human Dorsal Root Ganglion Neurons Reveals Novel Molecular and Cellular Mechanisms Underlying SomatosensationDOI 10.1101/2023.03.17.533207Read

Single-Soma Deep RNA Sequencing of Human Dorsal Root Ganglion Neurons Reveals Novel Molecular and Cellular Mechanisms Underlying SomatosensationSemantic proximity Read

Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensationSemantic proximity Read

A Reference Atlas of the Human Dorsal Root GanglionSemantic proximity Read

Single-cell transcriptomic profiling of dorsal root ganglion: an overviewSemantic proximity Read

Single nucleus transcriptomic analysis of human dorsal root ganglion neuronsSemantic proximity Read

Harmonized cross-species cell atlases of trigeminal and dorsal root gangliaSemantic proximity Read

Single-nucleus transcriptomic analysis of human dorsal root ganglion neuronsSemantic proximity Read

Translational insights into canine dorsal root ganglia cell types using cross-species comparisonsSemantic proximity Read

NOCICEPTRA2.0 - a comprehensive ncRNA atlas of human native and iPSC-derived sensory neuronsSemantic proximity Read

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neuronsSemantic proximity Read

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptorsSemantic proximity Read

Deep FLASH-seq profiling of purified canine sensory neurons uncovers species-specific signatures relevant to pain and itchSemantic proximity Read