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Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation

4 Nov 2024

Abstract excerpt

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes of individual human (h)DRG neurons-critical information to decipher their functions-are lacking due to technical difficulties. In this study, we isolated somata from individual hDRG neurons and conducted deep RNA sequencing (RNA-seq) to detect, on average, over 9,000 unique genes per...

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PMID: 39496796
DOI: 10.1038/s41593-024-01794-1

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