Article

Molecular architecture of human dermal sleeping nociceptors

2024-12-20

Abstract excerpt

Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains elusive, preventing targeted therapy. In this translational Patch-seq study, we combine single-cell transcriptomics following electrophysiological characterization with single-nucleus and...

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Literature Corpus work: 02cde585-c9cc-5af6-9310-efba8c791f9c
DOI: 10.1101/2024.12.20.629638

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