Article

Prenatal glycolysis restoration can rescue myocardial hypoplasia caused by platelet isoform of phosphofructokinase 1(PFKP) deficiency

2024-01-08

Abstract excerpt

<h4>Background</h4> Congenital myocardial hypoplasia affects heart function in congenital heart diseases, but its causes and mechanisms are unclear. <h4>Methods: </h4>: Fetuses with myocardial hypoplasia were examined using echocardiography imaging and genetic testing. The identified pathogenic genes were genetically targeted to validate mechanistic findings. We used stem cells and transgenic mice to understand mo...

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Literature Corpus work: 076d3018-5be3-5119-87ad-0cecc3544c0c
DOI: 10.1101/2024.01.07.24300871

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