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Article

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.

Developmental cell - 19 Dec 2016

Menendez-Montes Ivan, Escobar Beatriz, Palacios Beatriz, Gómez Manuel Jose, Izquierdo-Garcia Jose Luis, Flores Lorena, Jiménez-Borreguero Luis Jesus, Aragones Julian, Ruiz-Cabello Jesus, Torres Miguel, Martin-Puig Silvia

Abstract excerpt

While gene regulatory networks involved in cardiogenesis have been characterized, the role of bioenergetics remains less studied. Here we show that until midgestation, myocardial metabolism is compartmentalized, with a glycolytic signature restricted to compact myocardium contrasting with increased mitochondrial oxidative activity in the trabeculae. HIF1α regulation mirrors this pattern, with expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27997827
DOI: 10.1016/j.devcel.2016.11.012

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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