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Article

Friend of GATA2 Variant Ser657Gly Is Associated With Coronary Microvascular Disease.

Circulation. Genomic and precision medicine - 1 Apr 2026

Guerraty Marie A, Verma Shefali S, Ko Yi-An, McQuillan Michael A, Conlon Donna M, Tobias John W, Levin Michael G, Haury William, Zheng Fangyuan, Cherlin Tess, Zhang Chao, Judy Renae, Tishkoff Sarah A, Damrauer Scott M, Arany Zoltan, Rader Daniel J

Abstract excerpt

BACKGROUND: The coronary microvasculature is crucial for proper cardiac function, and coronary microvascular disease (CMVD) has emerged as an underdiagnosed and undertreated cause of ischemic heart disease. FOG2 (friend of GATA 2) is a transcriptional co-regulator crucial for coronary development and the maintenance of the coronary microvasculature in adult mice. Little is known about the role of FOG2 in humans...

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Share to Coronary Artery Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

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Share to Myocytes, Cardiac

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 41919390
DOI: 10.1161/CIRCGEN.125.005342
PMCID: PMC13102351

Genes

GATA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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