Article
The GATA1 N terminus coordinates metabolic reprogramming in erythropoiesis.
Blood - 28 May 2026
Ling Te, Bezavada Lavanya, Mehmood Rashid, Zhang Kevin, Cotton Anitria, Crawford Jeremy Chase, Jin Hongjian, Sona Surbhi, Li Lei, Ju Yan, Han Lei, Liu Nana, Tran Tam, Vu Hieu S, Jin Yan, Zhai Jinbin, Pruett-Miller Shondra M, Bhoopalan Senthil Velan, Xu Jian, Ni Min, Crispino John D
Abstract excerpt
ABSTRACT: Mutations in GATA1 that cause skipping of exon 2, which encodes the N terminus, are associated with the myeloid leukemia of Down syndrome and Diamond-Blackfan anemia (DBA). To elucidate the molecular function of this N-terminal region, we used single-cell RNA sequencing (scRNA-seq) on fetal liver cells from Gata1-mutant embryos that express only the short isoform of GATA1 (GATA1s) lacking the N terminus...
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