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Article

Placental Malperfusion Is Associated With Adverse Outcomes in Congenital Heart Disease and With Genetic Variants in Placental Developmental Pathways.

Journal of the American College of Cardiology - 11 Nov 2025

Josowitz Rebecca, Woyciechowski Stacy, Jadhav Tanaya, Jammihal Tejas, Linn Rebecca L, Rychik Jack, Gaynor J William, Rajagopalan Ramakrishnan, Spinner Nancy B

Abstract excerpt

BACKGROUND: Placental malperfusion (PMP), a vascular disorder of impaired maternal or fetal placental perfusion, is common in fetuses with congenital heart disease (CHD), yet its impact on outcomes and underlying mechanisms are unclear. Perturbation of shared developmental pathways between the fetal heart and placenta may play a role in PMP development. OBJECTIVE: This study sought to determine whether CHD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41193091
DOI: 10.1016/j.jacc.2025.07.069
PMCID: PMC12919346

Genes

MMP2
CHD7
COL4A4
DLL4
DSP
FN1
HNRNPK
ID2
NOTCH1
NOTCH3
PUF60
SMAD6
SOX9
SPON1
TIE1
VIM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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