Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The landscape of hereditary haemochromatosis risk and diagnosis across the British Isles and Ireland.

Nature communications - 3 Feb 2026

Kerr Shona M, Fletcher Benjamin S, Tzoneva Gannie, Shuldiner Alan R, Gilbert Edmund, Wilson James F

Abstract excerpt

Hereditary haemochromatosis is caused by pathogenic variants in the homoeostatic iron regulator gene HFE. Outcomes include liver cancer, cirrhosis and arthropathy, but penetrance is incomplete. Here, we use genetic data from >400,000 subjects to determine the genetic risk across 29 regions of the British Isles and Ireland. Northwest Irish and Outer Hebrideans are at the highest risk (1/54 - 1/62 carry the major...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Ireland

Share to Prevalence

Share to Risk Factors

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 41633988
DOI: 10.1038/s41467-025-65511-7
PMCID: PMC12868708

Genes

HFE
NHS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The landscape of hereditary haemochromatosis risk and diagnosis across the British Isles and Ireland.PMID 41633988Read ↗

Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK BiobankSemantic proximity Read ↗

<i>HFE</i>genotypes, haemochromatosis diagnosis and clinical outcomes to age 80: a prospective cohort study in UK BiobankSemantic proximity Read ↗

HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank.Semantic proximity Read ↗

Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes: prospective cohort study in UK BiobankSemantic proximity Read ↗

Penetrance of <i>HFE</i> haemochromatosis variants to clinical disease: polygenic risk score associations in UK BiobankSemantic proximity Read ↗

Haemochromatosis genetic variants and musculoskeletal outcomes: 11.5 year follow-up in the UK Biobank cohort studySemantic proximity Read ↗

Liver iron levels are associated with HFE-hemochromatosis genotype, diet, adiposity, and disease in the UK Biobank.Semantic proximity Read ↗

HFE-associated hereditary hemochromatosis: overview of genetics and clinical implications for nurse practitioners in primary care settings.Semantic proximity Read ↗

Genetic haemochromatosis.Semantic proximity Read ↗

Liver iron levels are associated with<i>HFE</i>-hemochromatosis genotype, diet, adiposity, and disease in the UK BiobankSemantic proximity Read ↗

Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy.Semantic proximity Read ↗

Unraveling genotype-phenotype relationships in hereditary hemochromatosis through integrated biobank data analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.