Article

PRISM: Recovering cell type specific expression profiles from composite RNA-seq data

2019-11-25

Abstract excerpt

A major challenge in analyzing cancer patient transcriptomes is that the tumors are inherently heterogeneous and evolving. We analyzed 214 bulk RNA samples of a longitudinal, prospective ovarian cancer cohort and found that the sample composition changes systematically due to chemotherapy and between the anatomical sites, preventing direct comparison of treatment-naive and treated samples. To overcome this, we dev...

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Literature Corpus work: b523b28c-c612-53c4-9170-fd4bcdb268c0
DOI: 10.1101/854505

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