Article

Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

2022-01-20

Abstract excerpt

<h4>ABSTRACT</h4> The heat shock (HS) response is crucial for cell survival in harmful environments. Nuclear lamin A/C, encoded by LMNA gene, has been shown to contribute towards altered gene expression during heat shock, but the underlying mechanisms are poorly understood. Here we show that reversible lamin A/C phosphorylation at Ser22 upon HS is an evolutionary conserved stress response that is triggered in co...

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Literature Corpus work: 07336cdc-3771-5c13-9018-f6ecebf795c6
DOI: 10.1101/2022.01.19.476880

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