Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.

doi:10.1016/0092-8674(90)90470-y

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Article

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.

Cell - 18 May 1990

Heald R, McKeon F

Abstract excerpt

The nuclear envelope is a dynamic structure that completely disassembles in response to MPF/cdc2 activity in mitosis. A key feature of this process is the hyperphosphorylation of the major structural proteins of the envelope, the nuclear lamins A, B, and C. Two highly conserved serine residues of...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cells, Cultured
Humans
Lamin Type A
Lamins
Macromolecular Substances
Mitosis
Molecular Sequence Data
Mutation
Nuclear Envelope
Nuclear Proteins
Phenotype
Phosphorylation
Recombinant Proteins
Structure-Activity Relationship
Transfection

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