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Article

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.

Cell - 18 May 1990

Heald R, McKeon F

Abstract excerpt

The nuclear envelope is a dynamic structure that completely disassembles in response to MPF/cdc2 activity in mitosis. A key feature of this process is the hyperphosphorylation of the major structural proteins of the envelope, the nuclear lamins A, B, and C. Two highly conserved serine residues of the lamin protein (Ser-22 and Ser-392 of lamins A and C) are symmetrically positioned 5 amino acids from the ends of...

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Identifiers

PMID: 2344612
DOI: 10.1016/0092-8674(90)90470-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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