Possible regulation of the immune modulator tetraspanin CD81 by alpha-synuclein in melanoma

Abstract excerpt

We probed the mechanism by which the Parkinsons disease-associated protein α–synuclein (α–syn)/ SNCA promotes the pathogenesis and progression of melanoma. We found that the human melanoma cell line SK–MEL–28 in which SNCA is knocked out ( SNCA -KO) has low levels of tetraspanin CD81, which is a cell-surface protein that promotes invasion, migration, and immune suppression. Analyzing data from the Cancer Genome...

Topics

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• Cell Adhesion Molecules Research
• Cellular transport and secretion
• Extracellular vesicles in disease
• Glycosylation and Glycoproteins Research
• Neuroinflammation and Neurodegeneration Mechanisms
• Parkinson's Disease Mechanisms and Treatments
• Retinal Development and Disorders
• RNA regulation and disease

Identifiers and source

Literature Corpus work

0723a790-98dd-55b6-a8e2-28ef92eb3095

DOI

10.1101/2024.05.09.593218