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Article

Casp8 acts through A20 to inhibit PD‐L1 expression: The mechanism and its implication in immunotherapy

2 May 2021

Abstract excerpt

Abstract Immunotherapy targeting the PD‐L1/PD‐1 pathway is a novel type of clinical cancer treatment, but only small subsets of patients can benefit from it because of multiple factors. PD‐L1/PD‐1 expression is a biomarker for predicting the efficacy of anti‐PD‐L1/PD‐1 therapy, which highlights the importance of understanding the regulatory mechanisms of PD‐L1 expression in cancer cells. Casp8 is an apical...

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PMID: 33934451
DOI: 10.1111/cas.14932

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