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Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory response

7 Nov 2024

Abstract excerpt

The Parkinson's disease protein, alpha-synuclein (α-syn/SNCA), is highly expressed in neurons and melanomas. The goal of this study was to reveal the mechanism(s) of α-syn's involvement in melanoma pathogenesis. To decipher the genes and pathways affected by α-syn, we conducted an RNA sequencing analysis of human SK-MEL-28 cells and several SK-MEL-28 SNCA-KO clones. We identified 1098 significantly up-regulated...

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PMID: 39511366
DOI: 10.1038/s41598-024-78777-6

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