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Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility

7 Jun 2023

Abstract excerpt

The Parkinson's disease (PD) associated protein, alpha-synuclein (α-syn/SNCA), is highly expressed in aggressive melanomas. The goal of this study was to reveal possible mechanism(s) of α-syn involvement in melanoma pathogenesis. Herein, we asked whether α-syn modulates the expression of the pro-oncogenic adhesion molecules L1CAM and N-cadherin. We used two human melanoma cell lines (SK-MEL-28, SK-MEL-29),...

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PMID: 37286800
DOI: 10.1038/s41598-023-36451-3

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