Article

Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain

2025-06-08

Abstract excerpt

Neuropathic pain is a highly prevalent condition for which treatments are hampered by low efficacy and dose-limiting side-effects. Injury to the somatosensory nervous system causes maladaptive plasticity that initiates and maintains chronic pain. Emerging evidence suggests that inflammatory cells of the innate immune system shape the response of the injured nervous system and thereby contribute to the pathogenesis...

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Literature Corpus work: 06828a7a-2d2a-5787-8862-d38c0308e236
DOI: 10.1101/2025.06.05.656880

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