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Article

Sex-specific molecular and cellular phenotypes during resolution of neuropathic pain in dorsal root ganglia.

Cell reports - 23 Jun 2026

Schlott Felicitas, Hartmannsberger Beate, Bischler Thorsten, Gräfenhan Tom, Brack Alexander, Rittner Heike L, Sodmann Annemarie, Blum Robert

Abstract excerpt

The dorsal root ganglion (DRG) is examined for sex-dependent phenotypes in sensory neurons, satellite glial cells (SGCs), and local macrophages following traumatic nerve injury and during natural pain resolution. Systematic analysis of 7,495 DRG immunofluorescence images and 62 transcriptomes reveals pronounced sex-specific, multicellular DRG phenotypes, particularly during pain resolution. Tissue size and neuron...

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Identifiers

PMID: 42207640
DOI: 10.1016/j.celrep.2026.117442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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