Article

Optimizing efficacy to safety ratio of glucocorticoids in rheumatoid arthritis models by leveraging PPARα agonism

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Glucocorticoids remain essential therapies for several immune- and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their (metabolic) side effects. Given the anti-inflammatory and metabolically favorable actions of peroxisome-proliferator activated nuclear receptor (PPAR) agonists, we investigated whether PPARα agonism could enhance the therapeut...

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Literature Corpus work: 0e28910b-42f2-5beb-8077-d815e39b59dc
DOI: 10.1101/2025.10.14.682304

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