Article

Natural language processing charts transcriptome evolution to design combination cancer therapies

2024-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Combination treatment–the mainstay of cancer therapy–often fails because treatment interactions evoke complex resistance mechanisms that are hard to predict. Designing combination therapy to prevent treatment resistance is especially challenging for rare cancers. Here, we introduce REsistance through COntext DRift (RECODR): a computational pipeline that tracks how genes change their transcriptom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 065a4b1a-91ad-5b39-b651-fc3efa465213
DOI: 10.1101/2024.04.09.585681

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Natural language processing charts transcriptome evolution to design combination cancer therapiesDOI 10.1101/2024.04.09.585681Read

A single-cell based precision medicine approach using glioblastoma patient-specific modelsSemantic proximity Read

Deciphering cancer therapy resistance via patient-level single-cell transcriptomics with CellResDBSemantic proximity Read

X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language ModelsSemantic proximity Read

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapySemantic proximity Read

Exploiting convergent evolution to derive a pan-cancer cisplatin response gene expression signatureSemantic proximity Read

Cancer vs. Conversational Artificial IntelligenceSemantic proximity Read

Perturbational Gene-Expression Signatures for Combinatorial Drug DiscoverySemantic proximity Read

OncoLoop: A network-based precision cancer medicine frameworkSemantic proximity Read

Clone-level multi-modal prediction of tumour drug responseSemantic proximity Read

Exploiting evolutionary steering to induce collateral drug sensitivity in cancer.Semantic proximity Read

A Generalized Evolutionary Classifier for Evolutionary Guided Precision MedicineSemantic proximity Read

Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional AdaptationSemantic proximity Read