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Article

V-ATPase regulation of Hypoxia Inducible transcription Factors

2018-01-01

Abstract excerpt

Metazoans have evolved conserved mechanisms to promote cell survival under low oxygen tensions by initiating a transcriptional cascade centered on the action of Hypoxia Inducible transcription Factors (HIFs). In aerobic conditions, HIFs are inactivated by ubiquitin-proteasome-mediated degradation of their a subunit, which is dependent on prolyl hydroxylation by 2-oxoglutarate (2-OG) and Fe(II)-dependent prolyl hyd...

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Literature Corpus work
0654b1f5-8bac-5fce-8100-3b311de602c7
DOI
10.17863/cam.30585
Open publication

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