Article

Development of a Structure-based Computational Simulation to Optimize the Blocking Efficacy of Pro-antibodies

2020-12-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The on-target toxicity of monoclonal antibodies (Abs) is mainly due to the fact that Abs cannot distinguish target antigens (Ags) expressed in disease regions from those in normal tissues during systemic administration. In order to overcome this issue, we “copied” an autologous Ab hinge as an “Ab lock” and “pasted” it on the binding site of the Ab by connecting...

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Literature Corpus work: 065377ef-d6fd-5446-9599-86c3a4291089
DOI: 10.21203/rs.3.rs-128660/v1

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