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Article

A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation.

PloS one - 1 Jan 2013

Zhang Ding, Chen Cai-Feng, Zhao Bin-Bin, Gong Lu-Lu, Jin Wen-Jing, Liu Jing-Jun, Wang Jing-Fei, Wang Tian-Tian, Yuan Xiao-Hui, He You-Wen

Abstract excerpt

1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and delivers antigen to dendritic cells (DCs). The potentially clinical application of this antibody is limited by its murine origin. Traditional humanization method such as complementarity determining regions (CDRs) graft often leads to a decreased or even lost affinity. Here we have developed a novel antibody humanization method...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24278299
DOI: 10.1371/journal.pone.0080636
PMCID: PMC3836750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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